EDC3

Enhancer of mRNA-decapping protein 3 is a protein that in humans is encoded by the EDC3 gene.^[5][6][7]

EDC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VC8, 2WAX, 2WAY, 3D3J, 3D3K
Identifiers
Aliases	EDC3, LSM16, YJDC, YJEFN2, MRT50, enhancer of mRNA decapping 3, hYjeF_N2-15q23
External IDs	OMIM: 609842; MGI: 2142951; HomoloGene: 11827; GeneCards: EDC3; OMA:EDC3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q24.1 Start 74,630,558 bp[1] End 74,696,292 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 57,615,823 bp[2] End 57,659,782 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis stromal cell of endometrium ganglionic eminence ventricular zone testicle islet of Langerhans gonad granulocyte right lobe of thyroid gland Top expressed in primitive streak hand otolith organ yolk sac Rostral migratory stream utricle otic vesicle external carotid artery trigeminal ganglion internal carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding phosphodiesterase decapping endonuclease activity identical protein binding RNA binding mRNA binding Cellular component cytoplasm cytosol membrane P-body cytoplasmic ribonucleoprotein granule Biological process P-body assembly exonucleolytic catabolism of deadenylated mRNA RNA phosphodiester bond hydrolysis, endonucleolytic deadenylation-independent decapping of nuclear-transcribed mRNA Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80153 353190 Ensembl ENSG00000179151 ENSMUSG00000038957 UniProt Q96F86 Q8K2D3 RefSeq (mRNA) NM_001142443 NM_001142444 NM_025083 NM_001351378 NM_001351379 NM_153799 RefSeq (protein) NP_001135915 NP_001135916 NP_079359 NP_001338307 NP_001338308 NP_722494 Location (UCSC) Chr 15: 74.63 – 74.7 Mb Chr 9: 57.62 – 57.66 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]^[7]