EDF1

Endothelial differentiation-related factor 1 is a protein that in humans is encoded by the EDF1 gene.^[5][6][7]

EDF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X57
Identifiers
Aliases	EDF1, EDF-1, MBF1, CFAP280, endothelial differentiation related factor 1
External IDs	OMIM: 605107; MGI: 1891227; HomoloGene: 2809; GeneCards: EDF1; OMA:EDF1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.3 Start 136,862,119 bp[1] End 136,866,308 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 25,447,859 bp[2] End 25,452,094 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland anterior pituitary body of pancreas right lobe of thyroid gland left lobe of thyroid gland mucosa of transverse colon duodenum right hemisphere of cerebellum jejunal mucosa body of stomach Top expressed in Paneth cell facial motor nucleus motor neuron fossa endothelial cell of lymphatic vessel condyle transitional epithelium of urinary bladder duodenum right kidney left lobe of liver More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity sequence-specific DNA binding DNA binding DNA-binding transcription factor activity transcription coactivator activity calmodulin binding histone acetyltransferase activity protein binding RNA binding TFIID-class transcription factor complex binding Cellular component cytoplasm transcription factor TFIID complex intracellular anatomical structure nucleolus extracellular exosome nucleus cytosol Biological process cell differentiation regulation of transcription, DNA-templated transcription, DNA-templated multicellular organism development positive regulation of transcription, DNA-templated regulation of lipid metabolic process endothelial cell differentiation positive regulation of DNA binding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8721 59022 Ensembl ENSG00000107223 ENSMUSG00000015092 UniProt O60869 Q9JMG1 RefSeq (mRNA) NM_153200 NM_001281297 NM_001281298 NM_001281299 NM_003792 NM_021519 RefSeq (protein) NP_001268226 NP_001268227 NP_001268228 NP_003783 NP_694880 NP_067494 Location (UCSC) Chr 9: 136.86 – 136.87 Mb Chr 2: 25.45 – 25.45 Mb PubMed search [3] [4]
Wikidata
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For the nuclear reactor EDF1, see Chinon Nuclear Power Plant.

Function

This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene.^[7]

Interactions

EDF1 has been shown to interact with:

• Liver X receptor alpha,^[8]
• Peroxisome proliferator-activated receptor gamma,^[8] and
• TATA binding protein.^[8][9][10]