EDIL3

EGF like repeats and discoidin domains 3 is a protein that in humans is encoded by the EDIL3 gene. ^[5]

EDIL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4D90
Identifiers
Aliases	EDIL3, DEL1, EGF like repeats and discoidin domains 3
External IDs	OMIM: 606018; MGI: 1329025; HomoloGene: 21166; GeneCards: EDIL3; OMA:EDIL3 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q14.3 Start 83,940,554 bp[1] End 84,384,880 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 C3 Start 88,969,591 bp[2] End 89,471,342 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in external globus pallidus inferior ganglion of vagus nerve pars reticulata subthalamic nucleus tibia pars compacta superior vestibular nucleus pons lateral nuclear group of thalamus ventral tegmental area Top expressed in lateral geniculate nucleus medial geniculate nucleus medial dorsal nucleus anterior horn of spinal cord globus pallidus calvaria deep cerebellar nuclei ventral tegmental area lateral hypothalamus suprachiasmatic nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding integrin binding metal ion binding extracellular matrix structural constituent Cellular component extracellular vesicle extracellular region extracellular exosome extracellular matrix collagen-containing extracellular matrix Biological process multicellular organism development cell adhesion positive regulation of cell-substrate adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10085 13612 Ensembl ENSG00000164176 ENSMUSG00000034488 UniProt O43854 O35474 RefSeq (mRNA) NM_001278642 NM_005711 NM_001037987 NM_010103 RefSeq (protein) NP_001265571 NP_005702 NP_001033076 NP_034233 Location (UCSC) Chr 5: 83.94 – 84.38 Mb Chr 13: 88.97 – 89.47 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior.