EEF1A2

Elongation factor 1-alpha 2 is a protein that in humans is encoded by the EEF1A2 gene.^[5][6][7]

EEF1A2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4C0S, 3C5J
Identifiers
Aliases	EEF1A2, EEF1AL, EF-1-alpha-2, EF1A, HS1, STN, STNL, EIEE33, MRD38, eukaryotic translation elongation factor 1 alpha 2, DEE33
External IDs	OMIM: 602959; MGI: 1096317; HomoloGene: 121568; GeneCards: EEF1A2; OMA:EEF1A2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 63,488,013 bp[1] End 63,499,239 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H4|2 103.6 cM Start 180,789,446 bp[2] End 180,798,807 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle apex of heart muscle of thigh paraflocculus of cerebellum right hemisphere of cerebellum frontal pole thoracic diaphragm Skeletal muscle tissue of rectus abdominis Brodmann area 10 cerebellar vermis Top expressed in perirhinal cortex entorhinal cortex CA3 field primary motor cortex subiculum superior colliculus habenula prefrontal cortex pontine nuclei triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding translation factor activity, RNA binding protein binding protein kinase binding GTPase activity translation elongation factor activity Cellular component myelin sheath soma cytoplasmic side of lysosomal membrane nucleus eukaryotic translation elongation factor 1 complex cytoplasm synapse Biological process positive regulation of apoptotic process regulation of chaperone-mediated autophagy translational elongation positive regulation of lipid kinase activity response to electrical stimulus protein biosynthesis response to inorganic substance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1917 13628 Ensembl ENSG00000101210 ENSMUSG00000016349 UniProt Q05639 P62631 RefSeq (mRNA) NM_001958 NM_007906 RefSeq (protein) NP_001949 NP_031932 Location (UCSC) Chr 20: 63.49 – 63.5 Mb Chr 2: 180.79 – 180.8 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas.

Clinical significance

This gene may be critical in the development of ovarian cancer.^[7]

Regulation

EEF1A2 is a direct target of miRNA-663 and miRNA-744.^[8]