EEF1D

Elongation factor 1-delta is a protein that in humans is encoded by the EEF1D gene.^[5]

EEF1D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MVM, 2MVN, 2N51
Identifiers
Aliases	EEF1D, EF-1D, EF1D, FP1047, eukaryotic translation elongation factor 1 delta
External IDs	OMIM: 130592; MGI: 1913906; HomoloGene: 23404; GeneCards: EEF1D; OMA:EEF1D - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 143,579,697 bp[1] End 143,599,541 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D3 Start 75,766,054 bp[2] End 75,781,405 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon apex of heart left ovary right ovary body of pancreas right lobe of thyroid gland prostate muscle layer of sigmoid colon body of uterus canal of the cervix Top expressed in primitive streak condyle fossa internal carotid artery somite endothelial cell of lymphatic vessel aortic valve ascending aorta external carotid artery hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding heat shock protein binding translation factor activity, RNA binding signal transducer activity translation elongation factor activity protein binding cadherin binding Cellular component cytoplasm endoplasmic reticulum nucleus eukaryotic translation elongation factor 1 complex fibrillar center cytosol Biological process regulation of transcription, DNA-templated regulation of cell death translational elongation mRNA transcription transcription, DNA-templated cellular response to ionizing radiation positive regulation of I-kappaB kinase/NF-kappaB signaling signal transduction protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1936 66656 Ensembl ENSG00000104529 ENSG00000273594 ENSMUSG00000055762 UniProt P29692 P57776 RefSeq (mRNA) NM_001130053 NM_001130054 NM_001130055 NM_001130056 NM_001130057 NM_001195203 NM_001289950 NM_001960 NM_032378 NM_001317743 NM_001330646 NM_001285429 NM_001285430 NM_001285431 NM_001285432 NM_001285433 NM_001285434 NM_023240 NM_029663 RefSeq (protein) NP_001123525 NP_001123527 NP_001123528 NP_001123529 NP_001182132 NP_001276879 NP_001304672 NP_001317575 NP_001951 NP_115754 NP_001272358 NP_001272359 NP_001272360 NP_001272361 NP_001272362 NP_001272363 NP_075729 NP_083939 Location (UCSC) Chr 8: 143.58 – 143.6 Mb Chr 15: 75.77 – 75.78 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit functions as guanine nucleotide exchange factor. It is reported that this subunit interacts with HIV-1 Tat, and thus it represses the translation of host-cell, but not HIV-1, mRNAs. Several alternatively spliced transcript variants have been found for this gene, however, the full length nature of only two variants has been determined.^[6]

Interactions

EEF1D has been shown to interact with Glycyl-tRNA synthetase,^[7] EEF1G^[8][9] and KTN1,^[10] and is predicted to interact with TMEM63A.^[11]