EFEMP2

EGF-containing fibulin-like extracellular matrix protein 2 is a protein that in humans is encoded by the EFEMP2 gene.^[4][5][6]

EFEMP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KL7
Identifiers
Aliases	EFEMP2, ARCL1B, FBLN4, MBP1, UPH1, EGF containing fibulin like extracellular matrix protein 2, EGF containing fibulin extracellular matrix protein 2
External IDs	OMIM: 604633; MGI: 1891209; HomoloGene: 32339; GeneCards: EFEMP2; OMA:EFEMP2 - orthologs
Gene location (Mouse) Chr. Chromosome 19 (mouse)[1] Band 19|19 A Start 5,523,982 bp[1] End 5,532,545 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium ascending aorta right coronary artery left coronary artery canal of the cervix left uterine tube popliteal artery myometrium left lobe of thyroid gland gastric mucosa Top expressed in calvaria stroma of bone marrow molar dermis decidua external carotid artery internal carotid artery ascending aorta umbilical cord efferent ductule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding extracellular matrix structural constituent protein binding Cellular component extracellular vesicle extracellular region basement membrane extracellular exosome extracellular space collagen-containing extracellular matrix Biological process elastic fiber assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30008 58859 Ensembl n/a ENSMUSG00000024909 UniProt O95967 Q9WVJ9 RefSeq (mRNA) NM_016938 NM_001164352 NM_021474 NM_001374680 RefSeq (protein) NP_058634 NP_001157824 NP_067449 NP_001361609 Location (UCSC) n/a Chr 19: 5.52 – 5.53 Mb PubMed search [2] [3]
Wikidata
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A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. EFEMP2 (also known as fibulin-4) contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is widely expressed in a range of adult and fetal tissues.^[6]

Interactions

EFEMP2 has been shown to interact with P53.^[7]