EGIS-12233

EGIS-12,233 is a drug with applications in scientific research, acting as a potent and selective antagonist for both the 5-HT₆ and 5-HT₇ serotonin receptor subtypes, with good selectivity over other receptors.^[1] It has been shown to increase dopamine release in cochlear tissue, suggesting a role for the 5-HT₆ and 5-HT₇ receptors in regulation of the hearing system.^[2]

EGIS-12233

Clinical data
ATC code	none
Identifiers
IUPAC name 5,7-dichloro-3-[4-[4-(4-chlorophenyl)piperazin-1-yl]butyl]-3-ethyl-indolin-2-one
CAS Number	869742-55-2 Y
PubChem CID	11525867
ChemSpider	9700653
ChEMBL	ChEMBL260870
CompTox Dashboard (EPA)	DTXSID501028191
Chemical and physical data
Formula	C24H28Cl3N3O
Molar mass	480.86 g·mol−1
3D model (JSmol)	Interactive image
SMILES c3cc(Cl)ccc3N4CCN(CC4)CCCCC1(CC)c2cc(Cl)cc(Cl)c2NC1=O
InChI InChI=1S/C24H28Cl3N3O/c1-2-24(20-15-18(26)16-21(27)22(20)28-23(24)31)9-3-4-10-29-11-13-30(14-12-29)19-7-5-17(25)6-8-19/h5-8,15-16H,2-4,9-14H2,1H3,(H,28,31) Key:NOWFIMHNXPZVSK-UHFFFAOYSA-N
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