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EI24

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

EI24
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Etoposide-induced protein 2.4 homolog is a protein that in humans is encoded by the EI24 gene.[5][6][7]

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This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms.[7]

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