EIF2A

Eukaryotic translation initiation factor 2A (eIF2A) is a protein that in humans is encoded by the EIF2A gene.^[5][6][7] The eIF2A protein is not to be confused with eIF2α, a subunit of the heterotrimeric eIF2 complex. Instead, eIF2A functions by a separate mechanism in eukaryotic translation.

EIF2A
Identifiers
Aliases	EIF2A, EIF-2A, MST089, MSTP004, MSTP089, CDA02, eukaryotic translation initiation factor 2A
External IDs	OMIM: 609234; MGI: 1098684; HomoloGene: 5969; GeneCards: EIF2A; OMA:EIF2A - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q25.1 Start 150,546,678 bp[1] End 150,586,016 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 D|3 28.58 cM Start 58,433,242 bp[2] End 58,464,922 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte tibialis anterior muscle pancreatic epithelial cell skin of arm body of pancreas Achilles tendon deltoid muscle myocardium of left ventricle mucosa of ileum monocyte Top expressed in genital tubercle tail of embryo ventricular zone epiblast hand muscle of thigh otolith organ utricle lobe of prostate esophagus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ribosome binding tRNA binding protein binding translation initiation factor activity mRNA binding cadherin binding Cellular component cytoplasm eukaryotic translation initiation factor 2 complex blood microparticle extracellular space cytosolic small ribosomal subunit Biological process translational initiation protein phosphorylation SREBP signaling pathway positive regulation of signal transduction ribosome assembly regulation of translation protein biosynthesis response to amino acid starvation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83939 229317 Ensembl ENSG00000144895 ENSMUSG00000027810 UniProt Q9BY44 Q8BJW6 RefSeq (mRNA) NM_032025 NM_001319043 NM_001319044 NM_001319045 NM_001319046 NM_001005509 RefSeq (protein) NP_001305972 NP_001305973 NP_001305974 NP_001305975 NP_114414 NP_001005509 Location (UCSC) Chr 3: 150.55 – 150.59 Mb Chr 3: 58.43 – 58.46 Mb PubMed search [3] [4]
Wikidata
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Function

eIF2A is a 65 kDa protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002).[supplied by OMIM]^[7] It may be important for translation initiation mediated by the HCV IRES under stress conditions, but this result has been debated.^[8][9]