Top Qs
Timeline
Chat
Perspective

EIF2AK3

Human protein and coding gene From Wikipedia, the free encyclopedia

EIF2AK3
Remove ads

Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the EIF2AK3 gene.[5][6][7][8]

Quick Facts Available structures, PDB ...
Remove ads

Function

The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins.[6]

Clinical significance

Patients with mutations in this gene develop Wolcott-Rallison syndrome.[9]

Interactions

EIF2AK3 has been shown to interact with DNAJC3,[10] NFE2L2,[11] and endoplasmic reticulum chaperone BiP (Hsp70).[12]

Inhibitors

References

Further reading

Loading related searches...

Wikiwand - on

Seamless Wikipedia browsing. On steroids.

Remove ads