EIF4E2

Eukaryotic translation initiation factor 4E type 2 is a protein that in humans is encoded by the EIF4E2 gene.^[5][6][7][8] It belongs to the eukaryotic translation initiation factor 4E family.

EIF4E2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JGB, 2JGC
Identifiers
Aliases	EIF4E2, 4E-LP, 4EHP, EIF4EL3, IF4e, eukaryotic translation initiation factor 4E family member 2, h4EHP
External IDs	OMIM: 605895; MGI: 1914440; HomoloGene: 128466; GeneCards: EIF4E2; OMA:EIF4E2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q37.1 Start 232,550,659 bp[1] End 232,583,644 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C5 Start 87,141,636 bp[2] End 87,168,210 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte sural nerve Achilles tendon gastrocnemius muscle rectum gingival epithelium mucosa of transverse colon muscle of thigh islet of Langerhans amniotic fluid Top expressed in internal carotid artery external carotid artery fossa condyle yolk sac primitive streak seminal vesicula endothelial cell of lymphatic vessel Paneth cell vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA cap binding translation factor activity, RNA binding protein binding translation initiation factor activity ubiquitin protein ligase binding RNA binding RNA 7-methylguanosine cap binding Cellular component cytoplasm cytosol mRNA cap binding complex eukaryotic translation initiation factor 4F complex Biological process translational initiation negative regulation of translation in utero embryonic development protein biosynthesis regulation of translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9470 26987 Ensembl ENSG00000135930 ENSMUSG00000026254 UniProt O60573 Q8BMB3 RefSeq (mRNA) NM_001276336 NM_001276337 NM_001282958 NM_004846 NM_001330201 NM_001330202 NM_001330203 NM_001039169 NM_001039170 NM_023314 NM_001347083 RefSeq (protein) NP_001263265 NP_001263266 NP_001269887 NP_001317130 NP_001317131 NP_001317132 NP_004837 NP_001034258 NP_001034259 NP_001334012 NP_075803 Location (UCSC) Chr 2: 232.55 – 232.58 Mb Chr 1: 87.14 – 87.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

EIF4E2 has been shown to interact with ARIH1.^[9]