EIF4EBP2

Eukaryotic translation initiation factor 4E-binding protein 2 is a protein that in humans is encoded by the EIF4EBP2 gene.^[5][6][7]

EIF4EBP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MX4, 3AM7
Identifiers
Aliases	EIF4EBP2, 4EBP2, PHASII, eukaryotic translation initiation factor 4E binding protein 2
External IDs	OMIM: 602224; MGI: 109198; HomoloGene: 3022; GeneCards: EIF4EBP2; OMA:EIF4EBP2 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q22.1 Start 70,404,145 bp[1] End 70,428,618 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 B4|10 32.21 cM Start 61,264,270 bp[2] End 61,288,440 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell internal globus pallidus parotid gland epithelium of colon amniotic fluid jejunal mucosa ganglionic eminence palpebral conjunctiva mucosa of ileum tendon of biceps brachii Top expressed in extensor digitorum longus muscle lactiferous gland tail of embryo genital tubercle plantaris muscle gallbladder Ileal epithelium superior surface of tongue transitional epithelium of urinary bladder yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding eukaryotic initiation factor 4E binding translation repressor activity translation initiation factor activity Cellular component cytoplasm postsynapse intracellular anatomical structure Biological process social behavior insulin receptor signaling pathway modulation of chemical synaptic transmission negative regulation of translation memory TOR signaling protein biosynthesis cAMP-mediated signaling regulation of translation negative regulation of translational initiation regulation of synaptic plasticity translational initiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1979 13688 Ensembl ENSG00000148730 ENSMUSG00000020091 UniProt Q13542 P70445 RefSeq (mRNA) NM_004096 NM_010124 RefSeq (protein) NP_004087 NP_004087.1 NP_034254 Location (UCSC) Chr 10: 70.4 – 70.43 Mb Chr 10: 61.26 – 61.29 Mb PubMed search [3] [4]
Wikidata
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Animal studies

EIF4EBP2 knockout mice have been used as an animal model of autism. Mice without the Eif4ebp2 gene exhibited autism-like symptoms, including poor social interaction, altered communication and repetitive behaviors. Knockout mice have high levels of Neuroligins.^[8]

Interactions

EIF4EBP2 has been shown to interact with EIF4E.^[5][9]