EIF5

Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene.^[5][6]

EIF5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E9H, 2G2K, 2IU1
Identifiers
Aliases	EIF5, EIF-5, EIF-5A, eukaryotic translation initiation factor 5, Eukaryotic initiation factor 5
External IDs	OMIM: 601710; MGI: 95309; HomoloGene: 49610; GeneCards: EIF5; OMA:EIF5 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.32 Start 103,333,544 bp[1] End 103,345,025 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 F1|12 61.03 cM Start 111,504,450 bp[2] End 111,513,186 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in postcentral gyrus Pons sperm external globus pallidus lateral nuclear group of thalamus superior frontal gyrus pars compacta inferior olivary nucleus superior vestibular nucleus oocyte Top expressed in otic placode medullary collecting duct renal corpuscle saccule otic vesicle blood human fetus lacrimal gland tail of embryo spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function translation initiation factor activity nucleotide binding translation factor activity, RNA binding GTP binding GTPase activity protein binding eukaryotic initiation factor eIF2 binding RNA binding cadherin binding GDP-dissociation inhibitor activity Cellular component nucleus plasma membrane cytoplasm cytosol Biological process regulation of translational initiation protein biosynthesis activation of GTPase activity formation of translation preinitiation complex translational initiation formation of cytoplasmic translation initiation complex Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1983 217869 Ensembl ENSG00000100664 ENSMUSG00000021282 UniProt P55010 P59325 RefSeq (mRNA) NM_183004 NM_001969 NM_173363 NM_178041 RefSeq (protein) NP_001960 NP_892116 NP_775539 NP_829887 Location (UCSC) Chr 14: 103.33 – 103.35 Mb Chr 12: 111.5 – 111.51 Mb PubMed search [3] [4]
Wikidata
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EIF5 is a GTPase-activating protein.^[7]