ELF1

E74-like factor 1 (ets domain transcription factor) is a protein that in humans is encoded by the ELF1 gene.^[5]

ELF1
Identifiers
Aliases	ELF1, E74 like ETS transcription factor 1, EFTUD1, RIA1
External IDs	OMIM: 189973; MGI: 107180; HomoloGene: 7303; GeneCards: ELF1; OMA:ELF1 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q14.11 Start 40,931,924 bp[1] End 41,061,440 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D3 Start 79,718,634 bp[2] End 79,819,934 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte monocyte lymph node bone marrow cells Achilles tendon nipple appendix gallbladder mucosa of pharynx urethra Top expressed in mesenteric lymph nodes decidua thymus mucosa of urinary bladder transitional epithelium of urinary bladder blood left colon spleen lumbar spinal ganglion left lung lobe More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process regulation of cytokine production positive regulation of transcription, DNA-templated cell differentiation regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II negative regulation of T cell receptor signaling pathway transcription by RNA polymerase II regulation of cytokine-mediated signaling pathway regulation of B cell receptor signaling pathway regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1997 13709 Ensembl ENSG00000120690 ENSMUSG00000036461 UniProt P32519 Q60775 RefSeq (mRNA) NM_001145353 NM_172373 NM_001370329 NM_001370330 NM_001370331 NM_001370332 NM_001286411 NM_001286412 NM_007920 RefSeq (protein) NP_001138825 NP_758961 NP_001357258 NP_001357259 NP_001357260 NP_001357261 NP_001273340 NP_001273341 NP_031946 Location (UCSC) Chr 13: 40.93 – 41.06 Mb Chr 14: 79.72 – 79.82 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and can act as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants.^[5]