ELK3

ETS domain-containing protein Elk-3 is a protein that in humans is encoded by the ELK3 gene.^[5][6]

ELK3
Identifiers
Aliases	ELK3, ERP, NET, SAP2, SAP-2, ETS transcription factor, ETS transcription factor ELK3
External IDs	OMIM: 600247; MGI: 101762; HomoloGene: 3833; GeneCards: ELK3; OMA:ELK3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q23.1 Start 96,194,375 bp[1] End 96,269,824 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C2|10 48.04 cM Start 93,083,276 bp[2] End 93,146,997 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell synovial joint amniotic fluid urethra visceral pleura vena cava parietal pleura oral cavity mucosa of paranasal sinus superficial temporal artery Top expressed in endothelial cell of lymphatic vessel dermis endocardial cushion left lung lobe atrioventricular valve atrium external carotid artery decidua vas deferens semi-lunar valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding transcription corepressor activity purine-rich negative regulatory element binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific Cellular component mitochondrion nucleoplasm cytoplasm nucleus Biological process transcription, DNA-templated cell differentiation wound healing regulation of transcription, DNA-templated angiogenesis signal transduction positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2004 13713 Ensembl ENSG00000111145 ENSMUSG00000008398 UniProt P41970 P41971 RefSeq (mRNA) NM_001303511 NM_005230 NM_001282967 NM_013508 NM_205536 NM_001322265 NM_001322268 RefSeq (protein) NP_001290440 NP_005221 NP_001269896 NP_001309194 NP_001309197 NP_038536 Location (UCSC) Chr 12: 96.19 – 96.27 Mb Chr 10: 93.08 – 93.15 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.^[6]

Interactions

ELK3 has been shown to interact with TCF3.^[7]