ELK4

ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.^[5][6][7]

ELK4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BC7, 1BC8, 1HBX, 1K6O
Identifiers
Aliases	ELK4, SAP1, ETS transcription factor, ETS transcription factor ELK4
External IDs	OMIM: 600246; MGI: 102853; HomoloGene: 1492; GeneCards: ELK4; OMA:ELK4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 205,597,556 bp[1] End 205,632,011 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 131,935,345 bp[2] End 131,960,350 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii epithelium of colon sperm epithelium of nasopharynx skin of thigh skin of hip biceps brachii superficial temporal artery parietal pleura seminal vesicula Top expressed in saccule Paneth cell otic placode semi-lunar valve hair follicle aortic valve blood conjunctival fornix thymus ankle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding sequence-specific DNA binding chromatin binding transcription coregulator activity protein binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm nucleus cytosol Biological process histone H3 deacetylation cell differentiation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2005 13714 Ensembl ENSG00000158711 ENSMUSG00000026436 UniProt P28324 P41158 RefSeq (mRNA) NM_001973 NM_021795 NM_007923 NM_001376954 NM_001376955 NM_001376956 NM_001376957 NM_001376958 NM_001376959 RefSeq (protein) NP_001964 NP_068567 NP_068567.1 NP_031949 NP_001363883 NP_001363884 NP_001363885 NP_001363886 NP_001363887 NP_001363888 Location (UCSC) Chr 1: 205.6 – 205.63 Mb Chr 1: 131.94 – 131.96 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.^[7]

Interactions

ELK4 has been shown to interact with:

• BRCA1,^[8] and
• Serum response factor^[9][10]