ELMO2

Engulfment and cell motility protein 2 is a protein that in humans is encoded by the ELMO2 gene.^[5][6]

ELMO2
Identifiers
Aliases	ELMO2, CED-12, CED12, ELMO-2, Ced-12A, engulfment and cell motility 2, VMPI
External IDs	OMIM: 606421; MGI: 2153045; HomoloGene: 44338; GeneCards: ELMO2; OMA:ELMO2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 46,366,050 bp[1] End 46,432,985 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 165,129,951 bp[2] End 165,168,399 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum cerebellar vermis caudate nucleus granulocyte right frontal lobe nucleus accumbens putamen C1 segment amygdala Top expressed in dentate gyrus of hippocampal formation granule cell visual cortex primary visual cortex superior frontal gyrus cerebellar cortex lobe of cerebellum genital tubercle cerebellar vermis tail of embryo piriform cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding receptor tyrosine kinase binding protein binding Cellular component cytosol membrane cytoplasm Biological process cell chemotaxis vascular endothelial growth factor receptor signaling pathway cell-cell adhesion cell migration cytoskeleton organization Fc-gamma receptor signaling pathway involved in phagocytosis phagocytosis apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63916 140579 Ensembl ENSG00000062598 ENSMUSG00000017670 UniProt Q96JJ3 Q5JVZ4 Q8BHL5 RefSeq (mRNA) NM_022086 NM_133171 NM_182764 NM_001318253 NM_080287 NM_207705 NM_207706 NM_001302752 NM_001302754 NM_207704 RefSeq (protein) NP_001305182 NP_573403 NP_877496 NP_001289681 NP_001289683 NP_525026 NP_997589 Location (UCSC) Chr 20: 46.37 – 46.43 Mb Chr 2: 165.13 – 165.17 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants encoding the same protein.^[6]