EMILIN1

Elastin microfibril interfacer 1 (EMILIN-1) is a protein that in humans is encoded by the EMILIN1 gene.^[5] It is the best characterized member of the EMILIN family of extracellular matrix glycoproteins.

EMILIN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KA3, 2OII
Identifiers
Aliases	EMILIN1, EMI, EMILIN, gp115, elastin microfibril interfacer 1
External IDs	OMIM: 130660; MGI: 1926189; HomoloGene: 5117; GeneCards: EMILIN1; OMA:EMILIN1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.3 Start 27,078,615 bp[1] End 27,086,403 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 B1 Start 31,070,746 bp[2] End 31,078,621 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery body of uterus left uterine tube right ovary muscle layer of sigmoid colon ascending aorta Descending thoracic aorta left ovary left coronary artery stromal cell of endometrium Top expressed in glomerulus glomerular basement membrane yolk sac body wall calvaria serosa of urinary bladder granulocyte right kidney embryo molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding extracellular matrix constituent conferring elasticity identical protein binding integrin binding involved in cell-matrix adhesion extracellular matrix structural constituent Cellular component collagen extracellular region extracellular exosome extracellular space extracellular matrix integrin alpha4-beta1 complex EMILIN complex collagen-containing extracellular matrix Biological process cell adhesion cell-matrix adhesion cell migration protein homotrimerization aortic valve morphogenesis positive regulation of gene expression negative regulation of gene expression positive regulation of cell-substrate adhesion negative regulation of angiogenesis extracellular matrix organization negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of vascular endothelial growth factor receptor signaling pathway negative regulation of collagen biosynthetic process elastic fiber assembly negative regulation of cell activation negative regulation of pathway-restricted SMAD protein phosphorylation negative regulation of ERK1 and ERK2 cascade positive regulation of extracellular matrix assembly negative regulation of collagen fibril organization negative regulation of macrophage migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11117 100952 Ensembl ENSG00000138080 ENSMUSG00000029163 UniProt Q9Y6C2 Q99K41 RefSeq (mRNA) NM_007046 NM_133918 RefSeq (protein) NP_008977 NP_598679 Location (UCSC) Chr 2: 27.08 – 27.09 Mb Chr 5: 31.07 – 31.08 Mb PubMed search [3] [4]
Wikidata
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For other uses, see Emilin.