ENTPD5

Ectonucleoside triphosphate diphosphohydrolase 5 is an enzyme that in humans is encoded by the ENTPD5 gene.^[5][6][7]

ENTPD5
Identifiers
Aliases	ENTPD5, CD39L4, NTPDase-5, PCPH, ectonucleoside triphosphate diphosphohydrolase 5, ectonucleoside triphosphate diphosphohydrolase 5 (inactive)
External IDs	OMIM: 603162; MGI: 1321385; HomoloGene: 37457; GeneCards: ENTPD5; OMA:ENTPD5 - orthologs
EC number	3.6.1.42
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.3 Start 73,958,010 bp[1] End 74,019,399 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 D1|12 39.18 cM Start 84,420,631 bp[2] End 84,455,803 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of sigmoid colon rectum jejunal mucosa duodenum liver mucosa of transverse colon right lobe of liver human kidney epithelium of colon mucosa of ileum Top expressed in proximal tubule right kidney human kidney left lobe of liver transitional epithelium of urinary bladder olfactory epithelium esophagus right ventricle jejunum duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function guanosine-diphosphatase activity uridine-diphosphatase activity protein binding hydrolase activity nucleoside-diphosphatase activity Cellular component endoplasmic reticulum extracellular region Biological process 'de novo' posttranslational protein folding ATP metabolic process protein glycosylation protein N-linked glycosylation cell population proliferation positive regulation of glycolytic process regulation of phosphatidylinositol 3-kinase signaling nucleobase-containing small molecule catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 957 12499 Ensembl ENSG00000187097 ENSMUSG00000021236 UniProt O75356 Q9WUZ9 RefSeq (mRNA) NM_001249 NM_001321984 NM_001321985 NM_001321986 NM_001321987 NM_001321988 NM_001330189 NM_001382256 NM_001382257 NM_001382258 NM_001382259 NM_001382260 NM_001382262 NM_001382263 NM_001026214 NM_001286049 NM_001286058 NM_007647 RefSeq (protein) NP_001240 NP_001308913 NP_001308914 NP_001308915 NP_001308916 NP_001308917 NP_001317118 NP_001369185 NP_001369186 NP_001369187 NP_001369188 NP_001369189 NP_001369191 NP_001369192 NP_001021385 NP_001272978 NP_001272987 NP_031673 Location (UCSC) Chr 14: 73.96 – 74.02 Mb Chr 12: 84.42 – 84.46 Mb PubMed search [3] [4]
Wikidata
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ENTPD5 is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases.^[7]