ENTPD6

Ectonucleoside triphosphate diphosphohydrolase 6 is an enzyme that in humans is encoded by the ENTPD6 gene.^[5][6]

ENTPD6
Identifiers
Aliases	ENTPD6, CD39L2, IL-6SAG, IL6ST2, NTPDase-6, dJ738P15.3, ectonucleoside triphosphate diphosphohydrolase 6 (putative), ectonucleoside triphosphate diphosphohydrolase 6
External IDs	OMIM: 603160; MGI: 1202295; HomoloGene: 68170; GeneCards: ENTPD6; OMA:ENTPD6 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p11.21 Start 25,195,693 bp[1] End 25,228,075 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 G3 Start 150,749,042 bp[2] End 150,771,675 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart right hemisphere of cerebellum right frontal lobe right auricle of heart nucleus accumbens mucosa of transverse colon middle frontal gyrus anterior pituitary caudate nucleus prefrontal cortex Top expressed in spermatocyte spermatid seminiferous tubule dorsomedial hypothalamic nucleus subiculum paraventricular nucleus of hypothalamus ventromedial nucleus anterior amygdaloid area dentate gyrus of hippocampal formation granule cell lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleoside-triphosphatase activity guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity uridine-diphosphatase activity hydrolase activity nucleoside-diphosphatase activity Cellular component integral component of membrane cell surface Golgi membrane plasma membrane membrane extracellular region extracellular space Golgi apparatus Biological process response to calcium ion response to magnesium ion nucleobase-containing small molecule catabolic process metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 955 12497 Ensembl ENSG00000197586 ENSMUSG00000033068 UniProt O75354 Q5QPI7 Q3U0P5 RefSeq (mRNA) NM_001114089 NM_001247 NM_001317941 NM_001322378 NM_001322379 NM_001322380 NM_001322381 NM_001322382 NM_001322383 NM_001322384 NM_001322385 NM_001322386 NM_001322387 NM_001322388 NM_001322389 NM_001322390 NM_001322391 NM_001322392 NM_001322393 NM_001322394 NM_001322395 NM_001322396 NM_001322397 NM_001322398 NM_172117 NM_001355068 RefSeq (protein) NP_001107561 NP_001238 NP_001304870 NP_001309307 NP_001309308 NP_001309309 NP_001309310 NP_001309311 NP_001309312 NP_001309313 NP_001309314 NP_001309315 NP_001309316 NP_001309317 NP_001309318 NP_001309319 NP_001309320 NP_001309321 NP_001309322 NP_001309323 NP_001309324 NP_001309325 NP_001309326 NP_001309327 NP_742115 NP_001341997 NP_001357558 NP_001357559 NP_001357560 Location (UCSC) Chr 20: 25.2 – 25.23 Mb Chr 2: 150.75 – 150.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

ENTPD6 is similar to E-type nucleotidases (NTPases). NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD6 contains 4 apyrase-conserved regions, which is characteristic of NTPases.^[6]