EPHA6

Ephrin type-A receptor 6 is a protein that in humans is encoded by the EPHA6 gene.^[5][6]

EPHA6
Identifiers
Aliases	EPHA6, EHK-2, EHK2, EK12, EPA6, HEK12, PRO57066, EPH receptor A6
External IDs	OMIM: 600066; MGI: 108034; HomoloGene: 56396; GeneCards: EPHA6; OMA:EPHA6 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q11.2 Start 96,814,581 bp[1] End 97,761,532 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C1.3 Start 59,473,846 bp[2] End 60,425,894 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis sperm testicle gonad muscle layer of sigmoid colon stromal cell of endometrium Achilles tendon prefrontal cortex left ovary Top expressed in dentate gyrus of hippocampal formation granule cell lumbar spinal ganglion Region I of hippocampus proper hippocampus proper primary visual cortex superior frontal gyrus zygote CA3 field tongue cartilage of the septum More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase activity ATP binding ephrin receptor activity molecular function receptor tyrosine kinase transmembrane signaling receptor activity transmembrane-ephrin receptor activity Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane nucleoplasm cellular component cytoplasm neuron projection receptor complex Biological process phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway protein phosphorylation peptidyl-tyrosine phosphorylation ephrin receptor signaling pathway biological process negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 285220 13840 Ensembl ENSG00000080224 ENSMUSG00000055540 UniProt Q9UF33 Q62413 RefSeq (mRNA) NM_001080448 NM_001278300 NM_001278301 NM_173655 NM_007938 RefSeq (protein) NP_001073917 NP_001265229 NP_001265230 NP_775926 NP_031964 Location (UCSC) Chr 3: 96.81 – 97.76 Mb Chr 16: 59.47 – 60.43 Mb PubMed search [3] [4]
Wikidata
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EphA6 may serve an important role in breast carcinogenesis and may pose as a novel prognostic indicator and therapeutic target for breast cancer, particularly in patients with steroid receptor negative expression and HER‑2 overexpression^[7]