EPRS

Bifunctional aminoacyl-tRNA synthetase is an enzyme that in humans is encoded by the EPRS gene.^[5][6]

EPRS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FYJ, 4HVC, 4K86, 4K87, 4K88, 5A34, 5BMU, 5A1N, 5A5H
Identifiers
Aliases	EPRS1, EARS, GLUPRORS, PARS, QARS, QPRS, PIG32, glutamyl-prolyl-tRNA synthetase, HLD15, glutamyl-prolyl-tRNA synthetase 1, EPRS
External IDs	OMIM: 138295; MGI: 97838; HomoloGene: 5870; GeneCards: EPRS1; OMA:EPRS1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q41 Start 219,968,600 bp[1] End 220,046,530 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H5 Start 185,095,241 bp[2] End 185,160,557 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland optic nerve secondary oocyte Achilles tendon lateral nuclear group of thalamus ventricular zone tibia islet of Langerhans external globus pallidus Brodmann area 23 Top expressed in otic placode Rostral migratory stream parotid gland saccule maxillary prominence human fetus mandibular prominence tail of embryo genital tubercle otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding RNA stem-loop binding ATP binding catalytic activity ligase activity aminoacyl-tRNA ligase activity GTPase binding RNA binding glutamate-tRNA ligase activity proline-tRNA ligase activity zinc ion binding protein homodimerization activity metal ion binding identical protein binding Cellular component membrane GAIT complex cytoplasm aminoacyl-tRNA synthetase multienzyme complex cytosol plasma membrane ribonucleoprotein complex Biological process regulation of translation tRNA aminoacylation metabolism protein biosynthesis tRNA aminoacylation for protein translation negative regulation of translation cellular response to interferon-gamma glutamyl-tRNA aminoacylation prolyl-tRNA aminoacylation cellular response to insulin stimulus long-chain fatty acid import into cell protein-containing complex assembly regulation of long-chain fatty acid import into cell Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2058 107508 Ensembl ENSG00000136628 ENSMUSG00000026615 UniProt P07814 Q8CGC7 RefSeq (mRNA) NM_004446 NM_029735 NM_001357474 RefSeq (protein) NP_004437 NP_084011 NP_001344403 Location (UCSC) Chr 1: 219.97 – 220.05 Mb Chr 1: 185.1 – 185.16 Mb PubMed search [3] [4]
Wikidata
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Not to be confused with European Parliamentary Research Service.

Gene

Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined.^[6]

Function

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species.^[6]

Phosphorylation of EPRS is reported to be essential for the formation of GAIT (Gamma-interferon Activated Inhibitor of Translation) complex that regulates the translation of multiple genes in monocytes and macrophages.^[7]

Interactions

EPRS has been shown to interact with POU2F1,^[8] Heat shock protein 90kDa alpha (cytosolic), member A1^[9] and IARS.^[10]