EPS8L1

Epidermal growth factor receptor kinase substrate 8-like protein 1 is an enzyme that in humans is encoded by the EPS8L1 gene.^[5][6]

EPS8L1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K2M, 2ROL
Identifiers
Aliases	EPS8L1, DRC3, EPS8R1, PP10566, EPS8 like 1
External IDs	OMIM: 614987; MGI: 1914675; HomoloGene: 15767; GeneCards: EPS8L1; OMA:EPS8L1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 55,072,020 bp[1] End 55,087,923 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A1 Start 4,463,673 bp[2] End 4,483,486 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube buccal mucosa cell skin of abdomen skin of leg amniotic fluid right lobe of thyroid gland left lobe of thyroid gland pancreatic ductal cell oral cavity minor salivary glands Top expressed in esophagus lip skin of external ear granulocyte conjunctival fornix skin of back neural layer of retina left lung lobe right lung lobe cornea More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding T cell receptor binding protein binding cadherin binding Cellular component ruffle membrane extracellular exosome cytoplasm cytosol plasma membrane protein-containing complex Biological process regulation of Rho protein signal transduction Rho protein signal transduction positive regulation of ruffle assembly regulation of molecular function Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54869 67425 Ensembl ENSG00000131037 ENSMUSG00000006154 UniProt Q8TE68 Q8R5F8 RefSeq (mRNA) NM_017729 NM_133180 NM_139204 NM_001290416 NM_026146 NM_001374622 RefSeq (protein) NP_060199 NP_573441 NP_001277345 NP_080422 NP_001361551 Location (UCSC) Chr 19: 55.07 – 55.09 Mb Chr 7: 4.46 – 4.48 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Several alternatively spliced transcript variants encoding different isoforms exist.^[6]