EPS8L3

Epidermal growth factor receptor kinase substrate 8-like protein 3 is an enzyme that in humans is encoded by the EPS8L3 gene.^[5][6]

EPS8L3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WXT
Identifiers
Aliases	EPS8L3, EPS8R3, EPS8 like 3, HYPT5
External IDs	OMIM: 614989; MGI: 2139743; HomoloGene: 15878; GeneCards: EPS8L3; OMA:EPS8L3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 109,750,080 bp[1] End 109,764,027 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.3 Start 107,784,545 bp[2] End 107,800,216 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon rectum mucosa of ileum gallbladder jejunal mucosa duodenum mucosa of sigmoid colon gastric mucosa pancreatic ductal cell testicle Top expressed in intestinal villus ileum duodenum epithelium of small intestine large intestine colon jejunum left colon crypt of lieberkuhn of small intestine zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding actin filament binding actin binding Cellular component cytoplasm plasma membrane ruffle membrane Biological process regulation of hair cycle Rho protein signal transduction regulation of Rho protein signal transduction positive regulation of ruffle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79574 99662 Ensembl ENSG00000198758 ENSMUSG00000040600 UniProt Q8TE67 Q91WL0 RefSeq (mRNA) NM_024526 NM_133181 NM_139053 NM_001319952 NM_133867 RefSeq (protein) NP_001306881 NP_078802 NP_573444 NP_620641 NP_598628 Location (UCSC) Chr 1: 109.75 – 109.76 Mb Chr 3: 107.78 – 107.8 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Alternatively spliced transcript variants encoding different isoforms exist.^[6]