ERCC excision repair 6 like, spindle assembly checkpoint helicase

ERCC excision repair 6 like, spindle assembly checkpoint helicase is a protein that in humans is encoded by the ERCC6L gene. ^[5]

ERCC6L
Identifiers
Aliases	ERCC6L, PICH, RAD26L, excision repair cross-complementation group 6 like, ERCC excision repair 6 like, spindle assembly checkpoint helicase
External IDs	OMIM: 300687; MGI: 2654144; HomoloGene: 44945; GeneCards: ERCC6L; OMA:ERCC6L - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq13.1 Start 72,204,657 bp[1] End 72,239,027 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X D Start 101,185,322 bp[2] End 101,200,697 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte gonad ventricular zone testicle embryo ganglionic eminence stromal cell of endometrium trabecular bone bone marrow mucosa of transverse colon Top expressed in primary oocyte zygote secondary oocyte tail of embryo genital tubercle epiblast primitive streak maxillary prominence ureter abdominal wall More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding nucleotide binding helicase activity protein binding hydrolase activity ATP binding DNA translocase activity Cellular component cytosol membrane chromosome chromosome, centromeric region kinetochore Biological process cell division cell cycle sister chromatid cohesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54821 236930 Ensembl ENSG00000186871 ENSMUSG00000051220 UniProt Q2NKX8 Q8BHK9 RefSeq (mRNA) NM_017669 NM_001009954 NM_146235 RefSeq (protein) NP_060139 NP_001009954 NP_666347 Location (UCSC) Chr X: 72.2 – 72.24 Mb Chr X: 101.19 – 101.2 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF2) family of proteins, and contains a SNF2-like ATPase domain and a PICH family domain. One distinguishing feature of this SWI/SNF protein family member is that during interphase, the protein is excluded from the nucleus, and only associates with chromatin after the nuclear envelope has broken down. This protein is a DNA translocase that is thought to bind double-stranded DNA that is exposed to stretching forces, such as those exerted by the mitotic spindle. This protein associates with ribosomal DNA and ultra-fine DNA bridges (UFBs), fine structures that connect sister chromatids during anaphase at some sites such as fragile sites, telomeres and centromeres. This gene is required for the faithful segregation of sister chromatids during mitosis, and the ATPase activity of this protein required for the resolution of UFBs before cytokinesis.