ERP29

Endoplasmic reticulum protein 29 (ERp29) is a chaperone protein that in humans is encoded by the ERP29 gene.^[5]

ERP29
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QC7
Identifiers
Aliases	ERP29, C12orf8, ERp28, ERp31, HEL-S-107, PDI-DB, PDIA9, endoplasmic reticulum protein 29
External IDs	OMIM: 602287; MGI: 1914647; HomoloGene: 4963; GeneCards: ERP29; OMA:ERP29 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.13 Start 112,013,348 bp[1] End 112,023,449 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 121,566,653 bp[2] End 121,590,569 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte beta cell trachea cardia granulocyte body of pancreas pylorus thymus bone marrow cell nipple Top expressed in supraoptic nucleus lip superior surface of tongue yolk sac corneal stroma gallbladder right kidney placenta dentate gyrus of hippocampal formation granule cell ankle joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chaperone binding protein homodimerization activity protein disulfide isomerase activity protein binding Cellular component endoplasmic reticulum lumen membrane melanosome transport vesicle smooth endoplasmic reticulum cell surface endoplasmic reticulum extracellular exosome Biological process positive regulation of protein phosphorylation regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of gene expression protein secretion positive regulation of gene expression protein unfolding intracellular protein transport negative regulation of protein secretion protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10961 67397 Ensembl ENSG00000089248 ENSMUSG00000029616 UniProt P30040 P57759 RefSeq (mRNA) NM_006817 NM_001034025 NM_026129 RefSeq (protein) NP_001029197 NP_006808 NP_080405 Location (UCSC) Chr 12: 112.01 – 112.02 Mb Chr 5: 121.57 – 121.59 Mb PubMed search [3] [4]
Wikidata
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Function

ERp29 is a reticuloplasmin, a protein which resides in the lumen of the endoplasmic reticulum (ER). The protein shows sequence similarity to the protein disulfide-isomerase family.^[6] However, it lacks the thioredoxin motif characteristic of this family, suggesting that this protein does not function as a disulfide isomerase.^[6] The protein dimerizes and is thought to play a role in the processing of secretory proteins within the ER. Alternative splicing results in multiple transcript variants encoding different isoforms.^[5]