ESCO1

Establishment of sister chromatid cohesion N-acetyltransferase 1 is a protein that in humans is encoded by the ESCO1 gene.^[5]

ESCO1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4MXE
Identifiers
Aliases	ESCO1, A930014I12Rik, CTF, ECO1, EFO1, ESO1, establishment of sister chromatid cohesion N-acetyltransferase 1
External IDs	OMIM: 609674; MGI: 1925055; HomoloGene: 62166; GeneCards: ESCO1; OMA:ESCO1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q11.2 Start 21,529,284 bp[1] End 21,600,884 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 10,566,507 bp[2] End 10,610,352 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell tendon of biceps brachii pancreatic epithelial cell tibialis anterior muscle secondary oocyte Achilles tendon deltoid muscle testicle gonad epithelium of nasopharynx Top expressed in saccule zygote primary oocyte secondary oocyte otic placode otic vesicle mesenteric lymph nodes lacrimal gland cumulus cell olfactory epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity acyltransferase activity metal ion binding N-acetyltransferase activity zinc ion binding peptide-lysine-N-acetyltransferase activity identical protein binding acetyltransferase activity Cellular component chromatin nucleus nucleoplasm chromosome Biological process post-translational protein acetylation cell cycle sister chromatid cohesion regulation of DNA replication peptidyl-lysine acetylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114799 77805 Ensembl ENSG00000141446 ENSMUSG00000024293 UniProt Q5FWF5 Q69Z69 RefSeq (mRNA) NM_052911 NM_001081222 NM_144542 RefSeq (protein) NP_443143 NP_001074691 Location (UCSC) Chr 18: 21.53 – 21.6 Mb Chr 18: 10.57 – 10.61 Mb PubMed search [3] [4]
Wikidata
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Function

ESCO1 belongs to a conserved family of acetyltransferases involved in sister chromatid cohesion.^[6]

See also

• Lysine N-acetyltransferase