EXOC2

Exocyst complex component 2 is a protein that in humans is encoded by the EXOC2 gene.^[5][6][7]

EXOC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HK6
Identifiers
Aliases	EXOC2, SEC5, SEC5L1, Sec5p, exocyst complex component 2, NEDFACH
External IDs	OMIM: 615329; MGI: 1913732; HomoloGene: 10122; GeneCards: EXOC2; OMA:EXOC2 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p25.3 Start 485,154 bp[1] End 693,139 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.2 Start 30,997,902 bp[2] End 31,158,076 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle middle temporal gyrus gonad secondary oocyte Brodmann area 23 islet of Langerhans ganglionic eminence Achilles tendon stromal cell of endometrium primary visual cortex Top expressed in hand genital tubercle otolith organ utricle superior cervical ganglion granulocyte zygote spermatocyte spermatid tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding protein kinase binding protein N-terminus binding Cellular component cytosol plasma membrane exocyst membrane Flemming body Biological process protein transport regulation of entry of bacterium into host cell Golgi to plasma membrane transport exocyst assembly exocytosis transport vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55770 66482 Ensembl ENSG00000112685 ENSMUSG00000021357 UniProt Q96KP1 Q9D4H1 RefSeq (mRNA) NM_018303 NM_025588 NM_001360093 RefSeq (protein) NP_060773 NP_079864 NP_001347022 Location (UCSC) Chr 6: 0.49 – 0.69 Mb Chr 13: 31 – 31.16 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts.^[7]