EXOC5

Exocyst complex component 5 is a protein that in humans is encoded by the EXOC5 gene.^[5][6]

EXOC5
Identifiers
Aliases	EXOC5, HSEC10, PRO1912, SEC10, SEC10L1, SEC10P, exocyst complex component 5
External IDs	OMIM: 604469; MGI: 2145645; HomoloGene: 38195; GeneCards: EXOC5; OMA:EXOC5 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q22.3 Start 57,200,507 bp[1] End 57,268,905 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C1 Start 49,241,547 bp[2] End 49,304,110 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence corpus callosum ventricular zone cardiac muscle tissue of right atrium myocardium of left ventricle inferior ganglion of vagus nerve Achilles tendon epithelium of colon subthalamic nucleus secondary oocyte Top expressed in hand superior cervical ganglion medial ganglionic eminence medullary collecting duct gastrula lumbar spinal ganglion foot cumulus cell epithelium of lens stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein N-terminus binding protein binding Cellular component cytoplasm cytosol exocyst midbody Biological process protein transport vesicle docking post-Golgi vesicle-mediated transport exocytosis Golgi to plasma membrane transport establishment of planar polarity homeostasis of number of cells within a tissue protein localization to plasma membrane epithelial cell apoptotic process non-motile cilium assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10640 105504 Ensembl ENSG00000070367 ENSMUSG00000061244 UniProt O00471 Q3TPX4 RefSeq (mRNA) NM_006544 NM_207214 RefSeq (protein) NP_006535 NP_997097 Location (UCSC) Chr 14: 57.2 – 57.27 Mb Chr 14: 49.24 – 49.3 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.^[6]

Interactions

EXOC5 has been shown to interact with Arf6.^[7]