EXOC6

Exocyst complex component 6 is a protein that in humans is encoded by the EXOC6 gene.^[5]

EXOC6
Identifiers
Aliases	EXOC6, EXOC6A, SEC15, SEC15L, SEC15L1, SEC15L3, Sec15p, exocyst complex component 6
External IDs	OMIM: 609672; MGI: 1351611; HomoloGene: 41305; GeneCards: EXOC6; OMA:EXOC6 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.33 Start 92,826,831 bp[1] End 93,059,493 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 C2|19 32.32 cM Start 37,509,327 bp[2] End 37,672,507 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in deltoid muscle pancreatic epithelial cell vastus lateralis muscle middle temporal gyrus tibialis anterior muscle buccal mucosa cell Skeletal muscle tissue of biceps brachii Skeletal muscle tissue of rectus abdominis islet of Langerhans placenta Top expressed in soleus muscle extraocular muscle digastric muscle sternocleidomastoid muscle temporal muscle intercostal muscle triceps brachii muscle granulocyte thoracic diaphragm Region I of hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component cytosol plasma membrane exocyst cytoplasm growth cone cell projection perinuclear region of cytoplasm Flemming body membrane Biological process protein transport vesicle docking involved in exocytosis exocytosis Golgi to plasma membrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54536 107371 Ensembl ENSG00000138190 ENSMUSG00000053799 UniProt Q8TAG9 Q8R313 RefSeq (mRNA) NM_001013848 NM_019053 NM_001319194 NM_001319195 NM_001319200 NM_175353 RefSeq (protein) NP_001013870 NP_001306123 NP_001306124 NP_001306129 NP_061926 n/a Location (UCSC) Chr 10: 92.83 – 93.06 Mb Chr 19: 37.51 – 37.67 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2.