Eyes absent homolog 2

Eyes absent homolog 2 is a protein that in humans is encoded by the EYA2 gene.^[5][6]

EYA2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3GEB, 3HB0, 3HB1, 4EGC
Identifiers
Aliases	EYA2, EAB1, EYA transcriptional coactivator and phosphatase 2
External IDs	OMIM: 601654; MGI: 109341; HomoloGene: 40711; GeneCards: EYA2; OMA:EYA2 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 46,894,624 bp[1] End 47,188,844 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H3|2 85.83 cM Start 165,436,952 bp[2] End 165,613,647 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa Achilles tendon parotid gland mucosa of esophagus nasal epithelium mucosa of paranasal sinus right uterine tube minor salivary glands tibial nerve mucosa of transverse colon Top expressed in nasal placode cranial nervi vagus nerve accessory nerve optic recess Jacobson's organ lip epithelium of stomach genital tubercle glossopharyngeal nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity metal ion binding protein binding protein tyrosine phosphatase activity hydrolase activity magnesium ion binding transcription factor binding Cellular component cytoplasm nucleoplasm mitochondrion nucleus cytosol Biological process striated muscle tissue development regulation of transcription, DNA-templated protein dephosphorylation transcription, DNA-templated cellular response to DNA damage stimulus multicellular organism development extrinsic apoptotic signaling pathway in absence of ligand mesodermal cell fate specification mitochondrial outer membrane permeabilization positive regulation of DNA repair peptidyl-tyrosine dephosphorylation DNA repair negative regulation of extrinsic apoptotic signaling pathway in absence of ligand chromatin organization anatomical structure development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2139 14049 Ensembl ENSG00000064655 ENSMUSG00000017897 UniProt O00167 O08575 RefSeq (mRNA) NM_005244 NM_172110 NM_172111 NM_172112 NM_172113 NM_001271962 NM_001271963 NM_010165 RefSeq (protein) NP_005235 NP_742108 NP_001258891 NP_001258892 NP_034295 Location (UCSC) Chr 20: 46.89 – 47.19 Mb Chr 2: 165.44 – 165.61 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the eyes absent (EYA) subfamily of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Five transcript variants encoding three distinct isoforms have been identified for this gene.^[6]

Interactions

EYA2 has been shown to interact with GNAI2^[7] and GNAZ.^[7]