GNAZ

Guanine nucleotide-binding protein G(z) subunit alpha is a protein that in humans is encoded by the GNAZ gene.^[5][6]

GNAZ
Identifiers
Aliases	GNAZ, G protein subunit alpha z, gz-alpha, HG1H
External IDs	OMIM: 139160; MGI: 95780; HomoloGene: 22574; GeneCards: GNAZ; OMA:GNAZ - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.22-q11.23 Start 23,070,519 bp[1] End 23,125,032 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 B5.3|10 38.48 cM Start 74,803,009 bp[2] End 74,852,739 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 frontal pole paraflocculus of cerebellum middle temporal gyrus C1 segment middle frontal gyrus right frontal lobe dorsolateral prefrontal cortex Brodmann area 9 anterior cingulate cortex Top expressed in ventromedial nucleus anterior amygdaloid area lateral septal nucleus mammillary body lateral hypothalamus subiculum dorsomedial hypothalamic nucleus arcuate nucleus prefrontal cortex median eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding G-protein beta/gamma-subunit complex binding signal transducer activity metal ion binding guanyl nucleotide binding GTP binding G protein-coupled receptor binding GTPase activity protein binding G protein-coupled serotonin receptor binding Cellular component cell body cytosol nuclear envelope membrane plasma membrane dendrite endoplasmic reticulum heterotrimeric G-protein complex Biological process G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway signal transduction protein folding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2781 14687 Ensembl ENSG00000128266 ENSMUSG00000040009 UniProt P19086 O70443 RefSeq (mRNA) NM_002073 NM_010311 NM_001358848 RefSeq (protein) NP_002064 NP_034441 NP_001345777 Location (UCSC) Chr 22: 23.07 – 23.13 Mb Chr 10: 74.8 – 74.85 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systems. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids.^[6]

Interactions

GNAZ has been shown to interact with EYA2,^[7] RGS20^[8][9] and RGS19.^[7][10]