EZH1

Histone-lysine N-methyltransferase EZH1 is an enzyme that in humans is encoded by the EZH1 gene.^[5][6]

EZH1
Identifiers
Aliases	EZH1, KMT6B, enhancer of zeste 1 polycomb repressive complex 2 subunit
External IDs	OMIM: 601674; MGI: 1097695; HomoloGene: 20458; GeneCards: EZH1; OMA:EZH1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 42,700,275 bp[1] End 42,745,049 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 64.37 cM Start 101,081,941 bp[2] End 101,117,289 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere right hemisphere of cerebellum tibial nerve dorsal motor nucleus of vagus nerve Achilles tendon left ovary sural nerve olfactory bulb right ovary canal of the cervix Top expressed in ciliary body iris motor neuron retinal pigment epithelium ankle zygote vestibular membrane of cochlear duct dentate gyrus of hippocampal formation granule cell granulocyte neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity chromatin binding histone-lysine N-methyltransferase activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding transcription corepressor activity Cellular component ESC/E(Z) complex nucleus nucleoplasm telomere Biological process histone H3-K27 methylation anatomical structure morphogenesis methylation regulation of transcription, DNA-templated hippocampus development transcription, DNA-templated positive regulation of transcription by RNA polymerase II chromatin organization negative regulation of transcription by RNA polymerase II chromatin remodeling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2145 14055 Ensembl ENSG00000108799 ENSMUSG00000006920 UniProt Q92800 P70351 RefSeq (mRNA) NM_001991 NM_001321079 NM_001321081 NM_001321082 NM_007970 RefSeq (protein) NP_001308008 NP_001308010 NP_001308011 NP_001982 NP_031996 NP_001390736 NP_001390738 NP_001390739 NP_001390740 NP_001390741 NP_001390742 NP_001390743 NP_001390744 NP_001390745 NP_001390747 NP_001390750 NP_001390751 Location (UCSC) Chr 17: 42.7 – 42.75 Mb Chr 11: 101.08 – 101.12 Mb PubMed search [3] [4]
Wikidata
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Function

In mice, EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair.^[7] EZH1 also complements EZH2 in maintaining stem cell identity and executing pluripotency.^[8]