Elongation factor for RNA polymerase II 2

Elongation factor for RNA polymerase II 2 is a protein that in humans is encoded by the ELL2 gene. ^[5]

ELL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E5N
Identifiers
Aliases	ELL2, elongation factor for RNA polymerase II 2, MRCCAT1
External IDs	OMIM: 601874; MGI: 2183438; HomoloGene: 8094; GeneCards: ELL2; OMA:ELL2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q15 Start 95,885,098 bp[1] End 95,961,851 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 C1 Start 75,854,876 bp[2] End 75,920,483 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland mucosa of paranasal sinus cartilage tissue Achilles tendon islet of Langerhans pancreatic epithelial cell gums oral cavity gingival epithelium lower lobe of lung Top expressed in seminal vesicula lacrimal gland parotid gland submandibular gland molar blood epithelium of lens epithelium of stomach human fetus body of femur More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component nucleus transcription elongation factor complex nucleoplasm Biological process regulation of transcription, DNA-templated transcription, DNA-templated transcription elongation from RNA polymerase II promoter snRNA transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22936 192657 Ensembl ENSG00000118985 ENSMUSG00000001542 UniProt O00472 Q3UKU1 RefSeq (mRNA) NM_012081 NM_138953 RefSeq (protein) NP_036213 NP_620403 Location (UCSC) Chr 5: 95.89 – 95.96 Mb Chr 13: 75.85 – 75.92 Mb PubMed search [3] [4]
Wikidata
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The encoded protein is a component of the superelongation complex (SEC) and drives immunoglobulin synthesis in plasma cells. Sequence variation in ELL2 has been associated with multiple myeloma and altered immunoglobulin levels.