Enterovirus cis-acting replication element

Enterovirus cis-acting replication element is a small RNA hairpin in the coding region of protein 2C as the site in PV1(M) RNA that is used as the primary template for the in vitro uridylylation.^[1][2] The first step in the replication of the plus-stranded poliovirus RNA is the synthesis of a complementary minus strand. This process is initiated by the covalent attachment of uridine monophosphate (UMP) to the terminal protein VPg, yielding VPgpU and VPgpUpU.

Enterovirus cis-acting replication element
Predicted secondary structure and sequence conservation of Entero_CRE
Identifiers
Symbol	Entero_CRE
Alt. Symbols	CRE
Rfam	RF00048
Other data
RNA type	Cis-reg
Domain(s)	Viruses
SO	SO:0000233
PDB structures	PDBe

See also

• Enteroviral 3′ UTR element
• Enterovirus 5′ cloverleaf cis-acting replication element