Erbin (protein)

Erbb2 interacting protein (ERBB2IP), also known as erbin, is a protein which in humans is encoded by the ERBB2IP gene.^[5] Discovered in 1997, erbin is a 200kDa protein containing a PDZ domain.^[6]

ERBIN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MFG, 1MFL, 1N7T, 2H3L, 2QBW, 3CH8
Identifiers
Aliases	ERBIN, HEL-S-78, LAP2, ERBB2IP, erbb2 interacting protein
External IDs	OMIM: 606944; MGI: 1890169; HomoloGene: 41282; GeneCards: ERBIN; OMA:ERBIN - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q12.3 Start 65,926,556 bp[1] End 66,082,546 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 D1 Start 103,955,295 bp[2] End 104,057,022 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum external globus pallidus optic nerve subthalamic nucleus internal globus pallidus inferior ganglion of vagus nerve pars reticulata medulla oblongata mucosa of paranasal sinus superior vestibular nucleus Top expressed in parotid gland submandibular gland left lung lobe left colon conjunctival fornix epithelium of small intestine lacrimal gland seminal vesicula Gonadal ridge mesenteric lymph nodes More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of cytoskeleton ErbB-2 class receptor binding protein binding signaling receptor binding Cellular component cytoplasm nuclear membrane membrane plasma membrane hemidesmosome basement membrane cell junction basal plasma membrane basolateral plasma membrane nucleus nuclear speck neuromuscular junction postsynapse glutamatergic synapse postsynaptic specialization Biological process negative regulation of monocyte chemotactic protein-1 production protein targeting epidermal growth factor receptor signaling pathway negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway cellular response to tumor necrosis factor response to muramyl dipeptide basal protein localization cell growth response to lipopolysaccharide cell adhesion establishment or maintenance of epithelial cell apical/basal polarity intermediate filament cytoskeleton organization integrin-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity signal transduction ERBB2 signaling pathway regulation of postsynaptic membrane neurotransmitter receptor levels Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55914 59079 Ensembl ENSG00000112851 ENSMUSG00000021709 UniProt Q96RT1 Q80TH2 RefSeq (mRNA) NM_001006600 NM_001253697 NM_001253698 NM_001253699 NM_001253701 NM_018695 NM_001005868 NM_021563 NM_001289473 NM_001289474 NM_001289475 RefSeq (protein) NP_001006600 NP_001240626 NP_001240627 NP_001240628 NP_001240630 NP_061165 NP_001005868 NP_001276402 NP_001276403 NP_001276404 Location (UCSC) Chr 5: 65.93 – 66.08 Mb Chr 13: 103.96 – 104.06 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date.^[5]

Clinical significance

Erbin's C-terminal PDZ domain is able to bind to ErbB2, a protein tyrosine kinase which is often associated with poor prognosis in epidermal oncogenesis.^[7] Erbin's N-terminal region has been shown to disrupt Ras to Raf binding and may be, through this action, a tumor suppressing protein.^[8]

Interactions

Erbin has been shown to interact with:

• Dystonin^[9]
• HER2/neu^[10][11][12]
• ITGB4^[9]
• Mothers against decapentaplegic homolog 3^[13]
• PKP4^[14][15][16] and
• KSR1^[17]