Estrogen-related receptor beta

Estrogen-related receptor beta (ERR-β), also known as ESRRB or NR3B2 (nuclear receptor subfamily 3, group B, member 2), is a nuclear receptor that in humans is encoded by the ESRRB (Estrogen Related Receptor Beta) gene .^[5]

ESRRB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LO1
Identifiers
Aliases	ESRRB, DFNB35, ERR2, ERRb, ESRL2, NR3B2, estrogen related receptor beta, ERRbeta2, ERR beta-2, Esrrb
External IDs	OMIM: 602167; MGI: 1346832; HomoloGene: 69108; GeneCards: ESRRB; OMA:ESRRB - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.3 Start 76,310,712 bp[1] End 76,501,837 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 D2|12 40.49 cM Start 86,407,891 bp[2] End 86,568,402 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle human kidney muscle of thigh apex of heart gastrocnemius muscle left ventricle renal medulla body of stomach right auricle of heart skeletal muscle tissue Top expressed in neural layer of retina stria vascularis chorion retinal pigment epithelium vestibular sensory epithelium morula lumbar subsegment of spinal cord blastocyst secondary oocyte ooblast More reference expression data BioGPS n/a
Gene ontology Molecular function steroid binding nuclear receptor activity zinc ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding transcription factor binding metal ion binding steroid hormone receptor activity transcription coactivator activity protein binding RNA polymerase II complex binding cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding Cellular component nucleus nucleoplasm condensed chromosome integrator complex chromosome cytoplasm Biological process regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II embryonic placenta development transcription, DNA-templated steroid hormone mediated signaling pathway transcription initiation from RNA polymerase II promoter intracellular receptor signaling pathway stem cell population maintenance negative regulation of transcription by RNA polymerase II cell population proliferation stem cell division cell dedifferentiation photoreceptor cell maintenance positive regulation of transcription, DNA-templated inner ear development positive regulation of transcription involved in G1/S transition of mitotic cell cycle positive regulation of transcription involved in G2/M transition of mitotic cell cycle positive regulation of stem cell population maintenance regulation of stem cell division negative regulation of stem cell differentiation positive regulation of glycogen biosynthetic process positive regulation of glycolytic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2103 26380 Ensembl ENSG00000119715 ENSMUSG00000021255 UniProt O95718 Q61539 RefSeq (mRNA) NM_004452 NM_001379180 NM_001159500 NM_011934 RefSeq (protein) NP_004443 NP_001366109 NP_001152972 NP_036064 Location (UCSC) Chr 14: 76.31 – 76.5 Mb Chr 12: 86.41 – 86.57 Mb PubMed search [3] [4]
Wikidata
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Function

ESRRB has been shown to be vital for the transition between a naïve pluripotent and primed pluripotent state in mammalian cells, and NANOG controls the expression of ESRRB in this scenario.^[6]