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Etrasimod

Medication From Wikipedia, the free encyclopedia

Etrasimod
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Etrasimod, sold under the brand name Velsipity, is a medication that is used for the treatment of ulcerative colitis.[6] It is a selective sphingosine-1-phosphate (S1P) receptor modulator that modifies the activity of the immune system.[6] It is taken by mouth.[6]

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The most common side effects include lymphopenia (low levels of lymphocytes) and headache.[8]

Etrasimod was discovered by Arena Pharmaceuticals, with subsequent development by Pfizer.[10] Etrasimod was approved for medical use in the United States in October 2023,[6] and in the European Union in February 2024.[8]

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Medical uses

Etrasimod is used for the treatment of moderate to severe ulcerative colitis.[6][8]

Mechanism of action

It works by causing T cells to become trapped in the lymph nodes, preventing them from entering the bloodstream, from where they would travel to other tissues in the body and mediate inflammation.[11][12][13][14][15][16]

Society and culture

Velsipity was approved by the US Food and Drug Administration (FDA) in October 2023.[6][17][18]

In December 2023, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Velsipity, intended for the treatment of ulcerative colitis.[8] The applicant for this medicinal product is Pfizer Europe MA EEIG.[8] Etrasimod was approved for medical use in the European Union in February 2024.[8]

Names

Etrasimod is the international nonproprietary name.[19]

References

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