Ets variant 2

Ets variant 2 is a protein that in humans is encoded by the ETV2 gene.^[5] It is a transcription factor and also plays a role in vascular endothelial cell development.^[6]

ETV2
Identifiers
Aliases	ETV2, ER71, ETSRP71, Ets variant 2, ETS variant transcription factor 2
External IDs	OMIM: 609358; MGI: 99253; HomoloGene: 7308; GeneCards: ETV2; OMA:ETV2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.12 Start 35,641,745 bp[1] End 35,644,871 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 B1 Start 30,333,041 bp[2] End 30,335,277 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis testicle mucosa of transverse colon stromal cell of endometrium granulocyte right lobe of liver skin of abdomen body of pancreas skin of leg Top expressed in embryo urethra male urethra primitive streak morula epiblast embryo seminiferous tubule blastocyst pharynx More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process Notch signaling pathway cell differentiation positive regulation of endothelial cell differentiation regulation of transcription, DNA-templated blood vessel morphogenesis placenta development regulation of transcription by RNA polymerase II mesoderm formation in utero embryonic development Wnt signaling pathway transcription by RNA polymerase II positive regulation of mesoderm development positive regulation of gene expression BMP signaling pathway involved in mesodermal cell fate specification erythrocyte differentiation blastocyst development positive regulation of transcription by RNA polymerase II hemopoiesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2116 14008 Ensembl ENSG00000105672 ENSMUSG00000006311 UniProt O00321 P41163 RefSeq (mRNA) NM_001300974 NM_001304549 NM_014209 NM_007959 RefSeq (protein) NP_001287903 NP_001291478 NP_055024 NP_031985 Location (UCSC) Chr 19: 35.64 – 35.64 Mb Chr 7: 30.33 – 30.34 Mb PubMed search [3] [4]
Wikidata
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