Exonuclease 5

Exonuclease 5 is a protein that in humans is encoded by the EXO5 gene. ^[5]

EXO5
Identifiers
Aliases	EXO5, C1orf176, DEM1, Exo V, hExo5, exonuclease 5
External IDs	MGI: 1920422; HomoloGene: 41497; GeneCards: EXO5; OMA:EXO5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.2 Start 40,508,741 bp[1] End 40,516,038 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 120,778,393 bp[2] End 120,782,214 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte buccal mucosa cell tendon of biceps brachii testicle granulocyte ganglionic eminence stromal cell of endometrium ventricular zone islet of Langerhans monocyte Top expressed in hand medial ganglionic eminence superior cervical ganglion secondary oocyte renal corpuscle medullary collecting duct trigeminal ganglion primary oocyte otolith organ zygote More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding 4 iron, 4 sulfur cluster binding nuclease activity iron-sulfur cluster binding single-stranded DNA 5'-3' exodeoxyribonuclease activity exonuclease activity protein homodimerization activity hydrolase activity single-stranded DNA 3'-5' exodeoxyribonuclease activity metal ion binding Cellular component cytosol nucleus nucleoplasm cytoplasm Biological process interstrand cross-link repair DNA repair cellular response to DNA damage stimulus nucleic acid phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64789 73172 Ensembl ENSG00000164002 ENSMUSG00000028629 UniProt Q9H790 Q9CXP9 RefSeq (mRNA) NM_001346946 NM_001346947 NM_001346948 NM_001346949 NM_001346950 NM_001346951 NM_001346952 NM_001346953 NM_001346954 NM_001346955 NM_001346956 NM_022774 NM_001160043 NM_028457 RefSeq (protein) NP_001333875 NP_001333876 NP_001333877 NP_001333878 NP_001333879 NP_001333880 NP_001333881 NP_001333882 NP_001333883 NP_001333884 NP_001333885 NP_073611 NP_001153515 NP_082733 Location (UCSC) Chr 1: 40.51 – 40.52 Mb Chr 4: 120.78 – 120.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a single-stranded DNA (ssDNA)-specific exonuclease that can slide along the DNA before cutting it. However, human replication protein A binds ssDNA and restricts sliding of the encoded protein, providing a 5'-directionality to the enzyme. This protein localizes to nuclear repair loci after DNA damage. [provided by RefSeq, Nov 2016].