Exosome component 4

Exosome component 4, also known as EXOSC4, is a human gene, which is part of the exosome complex.^[5]

EXOSC4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NN6
Identifiers
Aliases	EXOSC4, RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A, Exosome component 4
External IDs	OMIM: 606491; MGI: 1923576; HomoloGene: 6017; GeneCards: EXOSC4; OMA:EXOSC4 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 144,078,648 bp[1] End 144,080,648 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D3 Start 76,211,597 bp[2] End 76,214,877 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis mucosa of transverse colon apex of heart right adrenal gland left adrenal gland right adrenal cortex left adrenal cortex right lobe of liver gonad Top expressed in embryo right kidney otic placode yolk sac embryo proximal tubule otic vesicle medial ganglionic eminence facial motor nucleus ankle joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding exoribonuclease activity 3'-5'-exoribonuclease activity RNA binding mRNA 3'-UTR AU-rich region binding Cellular component cytoplasmic exosome (RNase complex) nuclear exosome (RNase complex) cytoplasm exosome (RNase complex) nucleolus nucleus nucleoplasm cytosol intermediate filament cytoskeleton Biological process defense response to virus rRNA 3'-end processing rRNA catabolic process polyadenylation-dependent snoRNA 3'-end processing U4 snRNA 3'-end processing nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' positive regulation of cell growth nuclear-transcribed mRNA catabolic process DNA deamination maturation of 5.8S rRNA regulation of mRNA stability nuclear mRNA surveillance exonucleolytic catabolism of deadenylated mRNA histone mRNA catabolic process rRNA processing RNA phosphodiester bond hydrolysis, exonucleolytic Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54512 109075 Ensembl ENSG00000178896 ENSMUSG00000034259 UniProt Q9NPD3 Q921I9 RefSeq (mRNA) NM_019037 NM_175399 RefSeq (protein) NP_061910 NP_780608 Location (UCSC) Chr 8: 144.08 – 144.08 Mb Chr 15: 76.21 – 76.21 Mb PubMed search [3] [4]
Wikidata
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Interactions

Exosome component 4 has been shown to interact with Exosome component 2.^[6]