FABP2

Fatty acid-binding protein 2 (FABP2), also known as Intestinal-type fatty acid-binding protein (I-FABP), is a protein that in humans is encoded by the FABP2 gene.^[5]

FABP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KZW, 1KZX, 2MJI, 2MO5, 3AKM, 3IFB
Identifiers
Aliases	FABP2, FABPI, I-FABP, fatty acid binding protein 2
External IDs	OMIM: 134640; MGI: 95478; HomoloGene: 107; GeneCards: FABP2; OMA:FABP2 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q26 Start 119,317,250 bp[1] End 119,322,138 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 G1|3 53.74 cM Start 122,688,721 bp[2] End 122,693,155 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon rectum jejunal mucosa duodenum mucosa of sigmoid colon testicle epithelium of colon appendix mucosa of ileum muscle tissue Top expressed in ileum jejunum duodenum migratory enteric neural crest cell epithelium of small intestine intestinal villus Ileal epithelium pyloric antrum Paneth cell mucous cell of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function fatty acid binding protein binding lipid binding long-chain fatty acid binding Cellular component cytoplasm cytosol intracellular anatomical structure Biological process triglyceride catabolic process intestinal lipid absorption Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2169 14079 Ensembl ENSG00000145384 ENSMUSG00000023057 UniProt P12104 P55050 RefSeq (mRNA) NM_000134 NM_007980 RefSeq (protein) NP_000125 NP_032006 Location (UCSC) Chr 4: 119.32 – 119.32 Mb Chr 3: 122.69 – 122.69 Mb PubMed search [3] [4]
Wikidata
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Function

The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells.^[5]

Clinical significance

This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance.^[5]