FABP6

Fatty acid binding protein 6, ileal (gastrotropin), also known as FABP6, is a protein which in humans is encoded by the FABP6 gene.^[5]

FABP6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1O1U, 1O1V, 2MM3
Identifiers
Aliases	FABP6, I-15P, I-BABP, I-BALB, I-BAP, ILBP, ILBP3, ILLBP, fatty acid binding protein 6
External IDs	OMIM: 600422; MGI: 96565; HomoloGene: 1108; GeneCards: FABP6; OMA:FABP6 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.3 Start 160,187,367 bp[1] End 160,238,735 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B1.1|11 25.81 cM Start 43,486,876 bp[2] End 43,492,367 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum right uterine tube bronchial epithelial cell olfactory zone of nasal mucosa nucleus accumbens caudate nucleus putamen testicle Hypothalamus substantia nigra Top expressed in crypt of lieberkuhn of small intestine Paneth cell ileum intestinal villus conjunctival fornix blastocyst epithelium of small intestine Ileal epithelium esophagus cornea More reference expression data BioGPS More reference expression data
Gene ontology Molecular function bile acid binding lipid binding Cellular component cytoplasm cytosol membrane Biological process lipid metabolism triglyceride catabolic process negative regulation of cell population proliferation lipid transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2172 16204 Ensembl ENSG00000170231 ENSMUSG00000020405 UniProt P51161 P51162 RefSeq (mRNA) NM_001040442 NM_001130958 NM_001445 NM_008375 RefSeq (protein) NP_001035532 NP_001124430 NP_001436 NP_032401 Location (UCSC) Chr 5: 160.19 – 160.24 Mb Chr 11: 43.49 – 43.49 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene.^[5]