FAM114A2

FAM114A2 (chromosome 5 open reading frame 3) is a gene on chromosome 5 in humans that encodes a protein FAM114A2. The protein function is not well known. FAM114A2 is, however, highly conserved in mammals with homologs both in fungi and plants.

Species	Accession #	Identity
macaca mulatta	XM_001102467	78.1%
Pan troglodytes	XM_518045	89.7%
bos taurus	NP_001033166	85.6%
Pongo abelii	XM_002816109	87.8%
Mus musculus	NM_026342.3	79%
Callithrix jacchus	XP_002744467	94.7%

FAM114A2
Identifiers
Aliases	FAM114A2, 133K02, C5orf3, family with sequence similarity 114 member A2
External IDs	MGI: 1917629; HomoloGene: 10270; GeneCards: FAM114A2; OMA:FAM114A2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.2 Start 153,990,148 bp[1] End 154,038,936 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 57,373,819 bp[2] End 57,409,443 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon Achilles tendon secondary oocyte sperm testicle Epithelium of choroid plexus islet of Langerhans body of pancreas left testis right testis Top expressed in seminal vesicula condyle Rostral migratory stream muscle of thigh granulocyte neural layer of retina ganglionic eminence saccule lacrimal gland vestibular sensory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function purine nucleotide binding Cellular component cellular component Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10827 67726 Ensembl ENSG00000055147 ENSMUSG00000020523 UniProt Q9NRY5 Q8VE88 RefSeq (mRNA) NM_018691 NM_001317993 NM_001317994 NM_001317995 NM_001168667 NM_001168668 NM_026342 RefSeq (protein) NP_001304922 NP_001304923 NP_001304924 NP_061161 NP_001162138 NP_001162139 NP_080618 Location (UCSC) Chr 5: 153.99 – 154.04 Mb Chr 11: 57.37 – 57.41 Mb PubMed search [3] [4]
Wikidata
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Protein

The FAM114A2 protein is 505 amino acids long^[5] with a molecular weight of 55.5 kdal and an isoelectric point of 4.66.^[6] It is predicted to stay in the nucleus after translation ^[7] There is evidence that c5orf3 interacts with another protein of unknown function from chromosome 5, c5orf4 ^[8] This protein is thought to include a P loop^[9] that suggests a role in ATP- and/or GTP-binding ^[10]

Gene

The FAM114A2 gene is located on chromosome 5 (5q31-33).^[11] This gene has 14 exons spanning through its sequence.^[5] The coding sequence is 2886 base pairs with a 5’ UTR of 94 base pairs and a 3’ UTR of 1273 base pairs.^[5] It is expressed at high levels in most tissues of the human body.^[11] It is also highly expressed in tissues in the human brain ^[12]