FAM135B

FAM135B is a human gene coding for a protein of unknown function.^[5] It is well conserved in primates, rodents, zebra fish. It has one paralog, FAM135A.

FAM135B
Identifiers
Aliases	FAM135B, C8ORFK32, family with sequence similarity 135 member B
External IDs	MGI: 1917613; HomoloGene: 66605; GeneCards: FAM135B; OMA:FAM135B - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.23 Start 138,130,023 bp[1] End 138,497,261 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D3 Start 71,303,458 bp[2] End 71,599,687 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis sperm right testis testicle cerebellar hemisphere right hemisphere of cerebellum gonad sural nerve pancreatic ductal cell islet of Langerhans Top expressed in spermatid seminiferous tubule spermatocyte dentate gyrus of hippocampal formation granule cell primary visual cortex superior frontal gyrus neural layer of retina cerebellar cortex supraoptic nucleus neural tube More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 51059 70363 Ensembl ENSG00000147724 ENSMUSG00000036800 UniProt Q49AJ0 Q9DAI6 RefSeq (mRNA) NM_015912 NM_001362965 NM_177819 RefSeq (protein) NP_056996 NP_001349894 NP_808487 Location (UCSC) Chr 8: 138.13 – 138.5 Mb Chr 15: 71.3 – 71.6 Mb PubMed search [3] [4]
Wikidata
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Gene

FAM135B is located on the long arm of Chromosome 8 in humans on the anti-sense located at 24.23.^[5] The following genes are near FAM135B on the chromosome:

• COL22A1: Collagen producing gene that is a cell adhesion ligand for skin epithelial cells and fibroblast
• FLJ45972: Gene function is unknown
• KCNK9: Gene that encodes for a two pore potassium channel

Expression

FAM135B is expressed in the brain, ear, eye, pancreas and testis.^[6] Within the brain, expression is apparent within the motor nucleus of trigeminal^[7] In addition, it is mainly expressed in normal health states, although it has shown moderate expression in glioma, non-neoplasima as well as expression in germ cell tumors.^[6]

Interactions

FAM135B has shown to interact with KAT5, a gene that encodes for a histone acetyltransferase^[8] through yeast two-hybrid experimentation.

Protein

The protein encoded on FAM135 is 1406 amino acids long. The protein contains a region called DUF676, believed to be a putative serine esterase as well as two protein regions called DUF3657.^[5]

Graphical representation of protein FAM135B

Clinical significance

FAM135B has shown to be expressed in individuals with extrapulmonary tuberculosis.^[9]