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FAM135B
Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
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FAM135B is a human gene coding for a protein of unknown function.[5] It is well conserved in primates, rodents, zebra fish. It has one paralog, FAM135A.
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Gene
FAM135B is located on the long arm of Chromosome 8 in humans on the anti-sense located at 24.23.[5] The following genes are near FAM135B on the chromosome:
Expression
FAM135B is expressed in the brain, ear, eye, pancreas and testis.[6] Within the brain, expression is apparent within the motor nucleus of trigeminal[7] In addition, it is mainly expressed in normal health states, although it has shown moderate expression in glioma, non-neoplasima as well as expression in germ cell tumors.[6]
Interactions
FAM135B has shown to interact with KAT5, a gene that encodes for a histone acetyltransferase[8] through yeast two-hybrid experimentation.
Protein
The protein encoded on FAM135 is 1406 amino acids long. The protein contains a region called DUF676, believed to be a putative serine esterase as well as two protein regions called DUF3657.[5]

Clinical significance
FAM135B has shown to be expressed in individuals with extrapulmonary tuberculosis.[9]
References
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