FAM49A

Family with sequence similarity 49, member A, also known as FAM49A, is a protein which in humans is encoded by the FAM49A gene.^[5]

FAM49A
Identifiers
Aliases	FAM49A, family with sequence similarity 49 member A
External IDs	MGI: 1261783; HomoloGene: 12657; GeneCards: FAM49A; OMA:FAM49A - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p24.2 Start 16,549,459 bp[1] End 16,666,331 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 A1.1|12 5.63 cM Start 12,312,140 bp[2] End 12,430,966 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 monocyte middle temporal gyrus superior frontal gyrus prefrontal cortex entorhinal cortex dorsolateral prefrontal cortex orbitofrontal cortex primary visual cortex lateral nuclear group of thalamus Top expressed in olfactory tubercle piriform cortex cingulate gyrus primary motor cortex subiculum anterior amygdaloid area visual cortex subdivision of hippocampus Region I of hippocampus proper nucleus accumbens More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 81553 76820 Ensembl ENSG00000197872 ENSMUSG00000020589 UniProt Q9H0Q0 Q8BHZ0 RefSeq (mRNA) NM_030797 NM_001146119 NM_029758 NM_001364432 RefSeq (protein) NP_110424 NP_001139591 NP_084034 NP_001351361 Location (UCSC) Chr 2: 16.55 – 16.67 Mb Chr 12: 12.31 – 12.43 Mb PubMed search [3] [4]
Wikidata
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Gene

Fam49A is located on human chromosome 2, at 2p24.3. It has 1512 base pairs in the reference sequence mRNA transcript.^[6]

Protein

The Fam49A gene product is a 323 amino acid protein. The protein contains two domains: Residues 15-319 comprise the "Domain of Unknown Function 1394" (DUF1394, Pfam PF07159). Residues 67->281 comprise the "Cytoplasmic Fragile X Interacting Superfamily" region.^[7]