FARSA (gene)

Phenylalanyl-tRNA synthetase alpha chain is an enzyme that in humans is encoded by the FARSA gene.^[5][6]

FARSA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3L4G
Identifiers
Aliases	FARSA, CML33, FARSL, FARSLA, FRSA, PheHA, phenylalanyl-tRNA synthetase alpha subunit, phenylalanyl-tRNA synthetase subunit alpha, RILDBC2
External IDs	OMIM: 602918; MGI: 1913840; HomoloGene: 3280; GeneCards: FARSA; OMA:FARSA - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.13 Start 12,922,479 bp[1] End 12,934,037 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C3 Start 85,583,618 bp[2] End 85,595,886 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex mucosa of transverse colon right frontal lobe cingulate gyrus anterior cingulate cortex Brodmann area 9 Brodmann area 10 gastrocnemius muscle apex of heart ganglionic eminence Top expressed in spermatocyte spermatid embryo morula embryo ventricular zone neural layer of retina blastocyst yolk sac lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function aminoacyl-tRNA ligase activity tRNA binding nucleotide binding ligase activity protein binding ATP binding phenylalanine-tRNA ligase activity RNA binding Cellular component cytoplasm cytosol membrane phenylalanine-tRNA ligase complex Biological process tRNA aminoacylation protein biosynthesis protein heterotetramerization tRNA aminoacylation for protein translation phenylalanyl-tRNA aminoacylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2193 66590 Ensembl ENSG00000179115 ENSMUSG00000003808 UniProt Q9Y285 Q8C0C7 RefSeq (mRNA) NM_004461 NM_025648 RefSeq (protein) NP_004452 NP_079924 Location (UCSC) Chr 19: 12.92 – 12.93 Mb Chr 8: 85.58 – 85.6 Mb PubMed search [3] [4]
Wikidata
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Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. This gene encodes a product which is similar to the catalytic subunit of prokaryotic and Saccharomyces cerevisiae phenylalanyl-tRNA synthetases (PheRS). This gene product has been shown to be expressed in a tumor-selective and cell cycle stage- and differentiation-dependent manner, the first member of the tRNA synthetase gene family shown to exhibit this type of regulated expression^[6]