FAT4

Protocadherin Fat 4, also known as cadherin family member 14 (CDHF14) or FAT tumor suppressor homolog 4 (FAT4), is a protein that in humans is encoded by the FAT4 gene.^[5][6]

FAT4
Identifiers
Aliases	FAT4, CDHF14, CDHR11, FAT-J, FATJ, NBLA00548, VMLDS2, HKLLS2, FAT atypical cadherin 4
External IDs	OMIM: 612411; MGI: 3045256; HomoloGene: 14377; GeneCards: FAT4; OMA:FAT4 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q28.1 Start 125,314,918 bp[1] End 125,492,932 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 B Start 38,941,089 bp[2] End 39,066,134 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon stromal cell of endometrium periodontal fiber epithelium of colon mucosa of paranasal sinus Descending thoracic aorta popliteal artery tibial arteries ventricular zone tibia Top expressed in hand internal carotid artery external carotid artery Gonadal ridge dermis vas deferens conjunctival fornix human fetus ascending aorta condyle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding calcium ion binding Cellular component integral component of membrane apical part of cell membrane intracellular anatomical structure plasma membrane extracellular exosome Biological process cerebral cortex development heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules neurogenesis heart morphogenesis regulation of metanephric nephron tubule epithelial cell differentiation kidney development plasma membrane organization digestive tract development inner ear receptor cell stereocilium organization ossification involved in bone maturation hippo signaling branching involved in ureteric bud morphogenesis cell adhesion nephron development fibroblast growth factor receptor signaling pathway Notch signaling pathway condensed mesenchymal cell proliferation cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79633 329628 Ensembl ENSG00000196159 ENSMUSG00000046743 UniProt Q6V0I7 Q2PZL6 RefSeq (mRNA) NM_001291285 NM_001291303 NM_024582 NM_183221 RefSeq (protein) NP_001278214 NP_001278232 NP_078858 NP_001278214.1 NP_001278232.1 NP_899044 Location (UCSC) Chr 4: 125.31 – 125.49 Mb Chr 3: 38.94 – 39.07 Mb PubMed search [3] [4]
Wikidata
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FAT4 is associated with the Hippo signaling pathway.^[7]

Clinical significance

Mutations in FAT4 are associated to Hennekam syndrome.^[8]