FBLN2

Fibulin-2 is a protein that in humans is encoded by the FBLN2 gene.^[5][6]

FBLN2
Identifiers
Aliases	FBLN2, fibulin 2
External IDs	OMIM: 135821; MGI: 95488; HomoloGene: 1514; GeneCards: FBLN2; OMA:FBLN2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.1 Start 13,549,125 bp[1] End 13,638,422 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 D1|6 40.42 cM Start 91,189,437 bp[2] End 91,249,522 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right auricle of heart right coronary artery subcutaneous adipose tissue abdominal fat left coronary artery apex of heart vena cava saphenous vein pericardium tibial nerve Top expressed in stroma of bone marrow umbilical cord external carotid artery internal carotid artery ankle joint decidua efferent ductule plantaris muscle lactiferous gland endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding extracellular matrix structural constituent extracellular matrix binding extracellular matrix constituent conferring elasticity Cellular component extracellular matrix extracellular vesicle extracellular exosome extracellular space extracellular region collagen-containing extracellular matrix Biological process positive regulation of cell-substrate adhesion extracellular matrix organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2199 14115 Ensembl ENSG00000163520 ENSMUSG00000064080 UniProt P98095 P37889 RefSeq (mRNA) NM_001004019 NM_001165035 NM_001998 NM_001081437 NM_007992 RefSeq (protein) NP_001004019 NP_001158507 NP_001989 NP_001074906 NP_032018 Location (UCSC) Chr 3: 13.55 – 13.64 Mb Chr 6: 91.19 – 91.25 Mb PubMed search [3] [4]
Wikidata
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This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal structures. Alternatively spliced transcript variants encoding different isoforms have been identified.^[6]

Its role as a biomarker for meningiomas (a common tumour affecting the central nervous system) was recently described where a blood test can predict whether patients have a grade II meningiomas (poor outcome) and not a grade I meningioma (better outcome), without the need for a surgical biopsy.^[7]

Interactions

FBLN2 has been shown to interact with Laminin, alpha 1,^[8][9] Laminin, alpha 5^[8] and Perlecan.^[10][11]