FBP1

Fructose-1,6-bisphosphatase 1 is a protein that in humans is encoded by the FBP1 gene.^[5]

FBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FTA, 2FHY, 2FIE, 2FIX, 2JJK, 2VT5, 2WBB, 2WBD, 2Y5K, 2Y5L, 3A29, 3KBZ, 3KC0, 3KC1, 4MJO
Identifiers
Aliases	FBP1, FBP, fructose-bisphosphatase 1
External IDs	OMIM: 611570; MGI: 95492; HomoloGene: 55467; GeneCards: FBP1; OMA:FBP1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q22.32 Start 94,603,133 bp[1] End 94,640,249 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B3 Start 63,012,567 bp[2] End 63,036,096 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver jejunal mucosa mucosa of ileum duodenum human kidney right lung upper lobe of left lung kidney tubule monocyte mucosa of transverse colon Top expressed in left lobe of liver right kidney human kidney seminiferous tubule gallbladder spermatocyte spermatid proximal tubule epithelium of small intestine Ileal epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding metal ion binding phosphoric ester hydrolase activity identical protein binding hydrolase activity catalytic activity monosaccharide binding AMP binding phosphatase activity fructose 1,6-bisphosphate 1-phosphatase activity Cellular component cytoplasm extracellular exosome cytosol nucleus Biological process fructose metabolic process fructose 6-phosphate metabolic process cellular response to magnesium ion metabolism dephosphorylation regulation of gluconeogenesis negative regulation of cell growth protein homotetramerization negative regulation of Ras protein signal transduction gluconeogenesis sucrose biosynthetic process fructose 1,6-bisphosphate metabolic process carbohydrate metabolic process negative regulation of transcription by RNA polymerase II negative regulation of glycolytic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2203 14121 Ensembl ENSG00000165140 ENSMUSG00000069805 UniProt P09467 Q9QXD6 RefSeq (mRNA) NM_000507 NM_001127628 NM_019395 RefSeq (protein) NP_000498 NP_001121100 NP_062268 Location (UCSC) Chr 9: 94.6 – 94.64 Mb Chr 13: 63.01 – 63.04 Mb PubMed search [3] [4]
Wikidata
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Function

Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.^[5]